@article {1266,
	title = {Opposing T cell responses in experimental autoimmune encephalomyelitis.},
	journal = {Nature},
	year = {2019},
	month = {2019 Aug 07},
	abstract = {<p>Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4, CD8 and γδ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find~major expansions of CD8 T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4 T cells are specific for the inducing myelin peptide MOG. By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8 T cells inhibit disease by suppressing the proliferation of MOG-specific CD4 T cells. These results suggest that the induction of autoreactive CD4 T cells triggers an opposing mobilization of regulatory CD8 T cells.</p>},
	issn = {1476-4687},
	doi = {10.1038/s41586-019-1467-x},
	author = {Saligrama, Naresha and Zhao, Fan and Sikora, Michael J and Serratelli, William S and Fernandes, Ricardo A and Louis, David M and Yao, Winnie and Ji, Xuhuai and Idoyaga, Juliana and Mahajan, Vinit B and Steinmetz, Lars M and Chien, Yueh-Hsiu and Hauser, Stephen L and Oksenberg, Jorge R and Garcia, K Christopher and Davis, Mark M}
}
