@article {709, title = {Incomplete vitreomacular traction release using intravitreal ocriplasmin.}, journal = {Case Rep Ophthalmol}, volume = {5}, year = {2014}, month = {2014 Sep-Dec}, pages = {455-62}, abstract = {

PURPOSE: To report the clinical course of our first 7 consecutive patients treated with intravitreal ocriplasmin (Jetrea(\®)).

METHODS: Retrospective case series of the first 7 patients treated with ocriplasmin between January and December 2013 at an academic tertiary care center.

RESULTS: The average age was 78.4 years (range: 63-92). Five patients were pseudophakic and 2 patients were phakic in the injected eye. The median baseline visual acuity (VA) was 20/60 (range: 20/25 to 20/200). The median 1-month postinjection VA was 20/70, with a mean loss of 2 lines of VA among all patients. None of the patients had complete resolution of their vitreomacular traction or macular hole at 1 month of follow-up. Three patients had subsequent pars plana vitrectomy and membrane peeling surgery. The mean follow-up period for those who did not undergo vitrectomy was 9 months (range: 1-13). One patient with known ocular hypertension had an increase in intraocular pressure requiring topical pressure-lowering eyedrops. There were no cases of postinjection uveitis, endophthalmitis, retinal tears, or retinal detachment.

CONCLUSIONS: While ocriplasmin may be a viable pharmacological agent for vitreolysis, we present a series of patients that all had incomplete resolution of vitreomacular traction with and without full-thickness macular hole. There was an associated reduction in VA after ocriplasmin treatment at 1 month of follow-up. Careful analysis of the vitreoretinal interface and comorbid eye conditions is required to optimize outcome success with ocriplasmin.

}, issn = {1663-2699}, doi = {10.1159/000370024}, author = {Chin, Eric K and Almeida, David R P and Sohn, Elliott H and Boldt, H Culver and Mahajan, Vinit B and Gehrs, Karen M and Russell, Stephen R and Folk, James C} }