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Phenomics Lab

High-throughput solutions for large-scale disease phenotyping.

We have established scalable, high-throughput phenotyping methods for characterizing human and mouse eye diseases. The mouse eye phenotype screening service is available to laboratories throughout the world. Through the development of cooperative laboratory networks, we hope to expand our screening effort.

Projects

We have established a scalable, multilevel, high-throughput phenotyping laboratory to identify mouse models for eye disease.

Capturing surgical events for careful clinical studies has always been a challenge.

News

Sep 30 2021 | Posted In: 20/20 Blog
 
Jul 6 2021 | Posted In: 20/20 Blog
Palo Alto, CA – As genetic testing and molecular biomarkers open new avenues for medical care, researchers are more reliant on samples from human subjects than ever.
Aug 19 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Retinal detachment surgery is an emergency procedure that prevents blindness, but research from Stanford’s Byers Eye Institute shows women may be treated differently than men.
Jun 15 2020 | Posted In: 20/20 Blog
Palo Alto, CA — Despite the near complete shutdown of in-person laboratory activities at the beginning of the COVID-19 pandemic, the Stanford Ophthalmology research laboratories remain incredibly productive.
Jun 8 2020 | Posted In: 20/20 Blog, Press
Palo Alto, Ca — Genetic testing doesn’t always provide a diagnosis, so Vinit Mahajan M.D., Ph.D., professor of ophthalmology at Stanford University, has applied proteomics to better understand disease in his patients. 
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Publications

Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness., Velez, Gabriel, and Mahajan Vinit B. , iScience, 2020 Nov 20, Volume 23, Issue 11, p.101667, (2020)
Optical Gap Biomarker in Cone-Dominant Retinal Dystrophy., Oh, Jin Kyun, Ryu Joseph, de Carvalho Jose Ronaldo Li, Levi Sarah R., Lee Winston, Tsamis Emmanouil, Greenstein Vivienne C., Mahajan Vinit B., Allikmets Rando, and Tsang Stephen H. , Am J Ophthalmol, 2020 May 20, (2020)
Retinal Manifestations of Mitochondrial Oxidative Phosphorylation Disorders., Oh, Jin Kyun, de Carvalho Jose Ronaldo Li, Nuzbrokh Yan, Ryu Joseph, Chemudupati Teja, Mahajan Vinit B., Sparrow Janet R., and Tsang Stephen H. , Invest Ophthalmol Vis Sci, 2020 Oct 01, Volume 61, Issue 12, p.12, (2020)
Fundoscopy-directed genetic testing to re-evaluate negative whole exome sequencing results., Cho, Ahra, de Carvalho Jose Ronaldo Li, Tanaka Akemi J., Jauregui Ruben, Levi Sarah R., Bassuk Alexander G., Mahajan Vinit B., and Tsang Stephen H. , Orphanet J Rare Dis, 2020 Jan 30, Volume 15, Issue 1, p.32, (2020)
Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes., Evans, Lucy P., Woll Addison W., Wu Shu, Todd Brittany P., Hehr Nicole, Hedberg-Buenz Adam, Anderson Michael G., Newell Elizabeth A., Ferguson Polly J., Mahajan Vinit B., et al. , J Neurotrauma, 2020 Mar 16, (2020)
Sex Does Not Influence Visual Outcomes After Blast-Mediated Traumatic Brain Injury but IL-1 Pathway Mutations Confer Partial Rescue., Evans, Lucy P., Boehme Nickolas, Wu Shu, Burghardt Elliot L., Akurathi Abhigna, Todd Brittany P., Newell Elizabeth A., Ferguson Polly J., Mahajan Vinit B., Dutca Laura M., et al. , Invest Ophthalmol Vis Sci, 2020 Oct 01, Volume 61, Issue 12, p.7, (2020)
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