Proteomics is the culmination of advances in chemistry, physics, bioinformatics, and molecular biology that allow the study of thousands of proteins simultaneously. A proteome can be defined as the complete set of proteins expressed in a particular cell or tissue of interest. This strategy is especially important in eye diseases where there are limited cell and animal models.
We are using proteomics to discover biomarkers, therapeutic targets, and molecular pathways involved in several eye diseases where diagnosis is difficult and current treatment is inadequate.
Proteomics Data Sets
Data sets from our proteomic studies of the eye are available as downloadable and searchable files.
Cold Spring Harbor Laboratories
Built in the late 1800's, the Jones lab is where DNA was identified as the heritable factor between cells.
Human Vitreous Proteomics
The vitreous is an optically clear, collagenous extracellular matrix that fills the inside of the eye and overlies the retina.
Proteomics of PVR
Proliferative vitreoretinopathy is the most common post-operative complication indicating failure of intravitreal surgical repair of rhegmatogenous retinal detachment (RRD).
Mouse Vitreous Proteomics
While the mouse retina has emerged as an important genetic model for inherited retinal disease, the mouse vitreous remains to